Toradol belongs to the drugs that selectively eliminate the pain, remove the heat, and provide anti-inflammatory effect. Medicine directionally inhibits the activity of the enzyme synthesizing prostanoids in nerve cells, which results in slowing down the formation of organic substances that provoke pain and inflammation. Toradol is a uniform mixture of both forms of stereoisomers. Reduced pain is achieved with the assistance of S-shape carbon. A preparation according to its effect on pain equated to narcotic drugs, being the leader in its group.
Toradol pharmacological action
Toradol has no effect on the receptors of the nervous system, regulating the symptoms of pain, does not restrict breathing, does not cause addiction, has no sedative and psychotropic effects on the nervous system. Toradol provides an analgesic effect after a half an hour after intramuscular administration of the drug, with the achievement of the best results with an interval of two hours.
The drug does not cause physical and mental abnormalities, such as the gag reflex, painful spasms in the abdomen, anxiety, seizures, impaired consciousness. Ketorolac, reducing platelet association, extend the period of bleeding.
Toradol is characterized by almost complete assimilation in the body. In the case of intramuscular injection bioavailability is achieved extremely fast. As a result, intramuscular injection of 30 mg of Toradol the quantity of blood of 3 ug/ml; when administered in the amount of 60 mg, the quantity of 6 mg/ml. is achieved. The period of greatest accumulation of the drug in the first case is equal up to 70 minutes, in the second one – up to an hour. The period to obtain the average concentration of medication in the case of intramuscular or intravenous injection is 24 hours. The therapy in this case carried out every six hours (the figure above therapeutically insignificant dose) and determined by intramuscular injection of 15 mg – over 1 ug/ml and 30 mg – about 3 ug/ml, by intravenous administration of 15 mg of Toradol – 1 g/ml, the application of 30 mg – 2 mg / ml.
Virtually all the dosage is synthesized with the proteins in the case of reducing the amount of albumin in blood serum below 35 grams/liter; while the concentration of the unbound substance in the blood plasma increases considerably. Patients with kidney disease have twice the amount of drug observed in the organism, the quantitative distribution of the pharmacologically active enantiomer increases to 20%.
Penetration through physiologic barrier between the circulatory system and central nervous system is characterized by insignificant impact, as a very small amount of the drug passes through the placental barrier (10%). Toradol in small amounts penetrates the breast milk. More than half of the administered drug dose is processed in the liver, resulting in the preparation of intermediates in metabolic cages do not react.
Toradol is processed in the liver with the advent of conjugated and oxidized forms. The main product of metabolism – gidroksiketorolak – is pharmacologically inactive.
In the form of tablets Toradol is taken periorally once or repeatedly, depending on the severity of pain. A single dose equals 10 mg, during repeated courses it is recommended to take 10 mg up to 4 times a day depending on the severity of pain; the maximum daily dose - 40 mg.
Note: the preparation can only be used after consultation with a treating doctor. In pregnancy, the treatment may be appointed only if the potential benefits outweigh the potential risk to the fetus, it is allowed for using only in case of emergency.