Nexium, an esomeprazole-based medication, heralded a new era of proton pump inhibitors. The drug demonstrates strong action in gastrointestinal tract diseases treatment, which is mainly achieved due to an increased acidity, bioavailability (in comparison with Omeprazole) and metabolism. The strong performance is achieved due to the structure of the preparation - it features a single proton pump inhibitor that develops as an isomer.
Isomerism phenomenon implies the compounds may same molecular formula but different structure; Such compounds are referred to as isomers. Nexium medication has an obvious advantage: it consists of one isomer (unlike 2-ispmer Omeprazole - the less efficient composition) and promotes fundamentally different metabolism.
Nexium: indications for use
Please, read the passage if you are looking to buy Nexium pills. After ingestion of Nexium, the process of metabolism is carried out in the liver and spread by blood flow throughout the body, reaching the proton pump of gastric parietal cells, where it begins to conduct its business. The process of its action in the body is different from the action of omeprazole: Nexium ieffectively participates in the process of metabolism, has a directed action, whereby the speed and duration of action is increased. A process for the treatment of diseases is associated with an imbalance of acid, which means:
• Improved and more predictable control of gastric acidity
• A greater percentage of cure in less time
• Clinical effect , backed by the experience of treatment: symptom relief and healing
• Suppression of heartburn and GERD symptom relief in a much larger number of patients.
With regard to more effective participation in the process of metabolism, Nexium is slowly decomposing in the liver, thus leaving the amount of drug to suppress (launch inhibition) of the gastric proton pump. At the same time, due to a more efficient metabolism and impressive drug's bioavailability (the exponent and the inflow rate of the drug substance in the blood of the injected dose in total is meant) is higher than in omeprazole, and this advantage occurs after the first dose. At the end of five days of treatment, this advantage is estimated at nearly 100%.
Nexium: how to use
Nexium effect, (at a dosage of 20 - 40mg) develops within an hour after oral administration. Patients with gastroesophageal reflux disease (GERD) and the presence of clinical symptoms are typically prescribed for 5 days of daily oral administration (20 mg or 40 mg), after which the pH value was maintained for an average of 13 and 17 hours of 24 hours. In patients receiving esomeprazole at a dose of 20 mg per day, the value of intragastric pH level above 4 was maintained for at least 8 , 12 and 16 hours in 76%, 54% and 24% of patients respectively. To 40 mg of esomeprazole, the ratio was equal to 97%, 92% and 56 % respectively.
Use of the drug Nexium to treat GERD in children (aged 1-11 years)
Erosive esophagitis and endoscopy treating effect was observed in 93.3% of patients aged 1-11 years after 8 weeks of therapy with Nexium. Patients weighing less than 20 kg received Nexium in a daily dose of 5 mg or 10 mg, and patients weighing more than 20 kg were prescribed a daily dose of 10 mg or 20 mg.
The preparation is manufactured in the form of the following dosage forms (tablets):
• 40 mg to 14 pcs. per package
• 20 mg to 14 pcs. per package
• 20 mg at 7 pcs. in package
The market also offers the options for intravenous administration in 40 mg packages and granules for oral suspension of 10 mg and 28 packets per box.