The instructions to clozapine reports that in most cases patients should take 200-400 mg per day. The exact dosage prescribed by your doctor, taking into account the nature of the disease and the patient's individual characteristics. The treatment should begin with small doses – 25-50 mg per day with a gradual increase in the daily dose for one to two weeks. The drug is better be taken before bedtime (though the daily dosage may be divided and a few parts). The treatment course is abandoned gradually, reducing the dosage within two weeks.
After finishing the course of treatment with a supporting course during which adopted by 25-200 mg of the drug is prescribed. Adjustment of the dose is performed for patients with liver, renal and cardiac insufficiency, and also in patients with cerebrovascular disorders. For the normalization of sleep taking the drug in smaller doses of 25-50 mg per day is recommended. The maximum allowable daily dose equals 600 mg. The attending physician may prescribe intramuscular injection of the drug. Children should take Clozapine in solution for oral administration for the preparation in which water diluted with 10.5 ml of granules. A single dose may vary from 5 to 20 mg, the dosage is chosen according to the age and weight of the child. The maximum allowable daily dose is 100 mg.
According to the instructions clozapine is contraindicated in individual intolerance of the main components of the drug; in the presence of granulocytopenia or agranulocytosis in history; toxic psychosis (alcoholic in particular) and suppression of bone marrow hematopoiesis.