Avodart pharmacological action
Avodart is a hormonal medication designed the prevention and treatment of benign (non-cancerous) prostate enlargement; as well as dealing with alopecia (hair loss) in men. Prostate enlargement is a very common disease in the 21st century, which mainly manifested in 40+ years old and even younger individuals.
Avodart medicament is typically offered in the form of capsules 0.5 mg of sealed blisters. Commercially available boxes contain 30 – 90 capsules. Apart from French company GlaxoSmithKline, the medication is produced in the form of generics at extremely affordable prices.
For various reasons, at some point the male body activates conversion of testosterone into DHT – the hormone that stimulates the proliferation of the glandular tissue of the prostate gland. Dutasteride, the medicament’s main active ingredient, inhibits the activity of 5a-reductase types I and II enzymes, which play a major role in the conversion of testosterone to dihydrotestosterone. The greatest influence on Avodart reduction in serum DHT observed after 1-2 weeks of medication course. By the end of second week, the concentration is reduced by 90%.
The drug is characterized by extremely high (over 99%) degree of plasma protein binding. Avodart undergoes extensive metabolism in the liver, which provides an extra load on the organ. The medication is excreted with 5-6% of non-modified dutasteride with feces.
Indications for use
Avodart is prescribed in case of a benign increase in the glandular tissue of the prostate gland, increasing the amount of prostate-specific antigen in the blood, as well as symptoms such as frequent urination, urinary retention, and etc. The decision to appoint Avodart is made on the basis of examination of the patient.
As a result, regular supplement use is often possible to achieve reduction of the size of the prostate and acute urine delays. It is admitted that the drug course may serve as alternative to surgical intervention.
Study drug was significantly showed that the effect of Avodart does not depend on the patient's age, so the men of advanced years get the same dose as younger patients. Avodart may be appointed as the sole drug for the prevention and treatment of prostatic hyperplasia, but most doctors prescribe it in combination with other drugs: in particular, with tamsulosin.
The medication may lead to a slight decrease in ejaculate, reduced sperm count and reduced erection. However, these changes are not significant, since it does not exceed 30%, so the Avodart has no significant impact on the ability of man to conceive.
According to the instructions, Avodart is accepted regardless of the meal and the time of day. Renal failure is not an obstacle for prescription and use of the drug. In case of liver failure taking Avodart is not recommended (generally, in the presence of liver disease, doctors usually do not prescribe such agents). Consult your doctor before starting Avodart course.
According to the recipe, Avodart is taken once a day (one capsule). The capsules are swallowed whole, without opening and without chewing, as the contents of the capsules can cause irritation of the mucous membranes of the mouth and pharynx. Reducing the symptoms of the disease can occur in the first weeks of receiving the drug, but the treatment should not be less than 6 months.
After reaching the therapeutic effect the doctor may decide to reduce the dosage of the drug and prescribe reception capsules once a day, as a maintenance therapy.
The medications must not be prescribed to women and children. An active substance contained in the capsules is characterized by skin absorbing properties, so it is not recommended to disassemble the capsule and/or touch its content.