Advair drug has a noteworthy anti-inflammatory, anti-allergic and anti-edema effect; typically prescribed for asthma treatment. The anti-inflammatory effect is realized by the interaction of the drug with the GCS receptors. The medication inhibits the proliferation of mast cells, eosinophils, lymphocytes, macrophages and neutrophils.
Advair: indications for use
Fluticasone, the active ingredient of Advair, reduces the production of inflammatory mediators and other biologically active substances (histamine, PG and leukotrienes) during the early and late phases of allergic reactions. The drug restores the patient's response to bronchodilators, allowing you to reduce the frequency of their use. The preparation reduces sneezing, itchy nose, runny nose, nasal congestion, discomfort in the sinuses and the feeling of pressure around the nose and eyes. Furthermore, it facilitates ocular symptoms associated with allergic rhinitis.
Inhaled forms of preparation: basic anti-inflammatory treatment of asthma. Nasal spray: prevention and treatment of allergic rhinitis.
Fluticasone is also available for external use in the form of creams and ointments. The drug is used in children and adults to reduce the symptoms of inflammation and relieve itching in acute and chronic dermatoses, measurable SCS therapy. Fluticasone may also be used to reduce the risk of relapse in chronic atopic eczema, if marked therapeutic effect in the treatment of the acute phase of the disease.
Advair: dosage and administration
Inhaled forms of preparation:
• Adults and children over 16 years are prescribed 100 mg 2 times a day every day.
• In bronchial asthma, appointed a dose of 100-250 mg 2 times a day.
• In bronchial asthma, moderate flow - 250-500 mg 2 times a day.
• In bronchial asthma, severe course - 500 mg 2 times a day.
• Children older than 4 years, depending on the severity of asthma appoint 50-100 mg 2 times a day every day.
The dose of drug may be corrected depending on the individual patient response.
Fluticasone nasal spray: adults and children over 12 years are typically appointed 100 mcg in each nostril, preferably in the morning. If needed, 100 mg 2 times a day. The maximum daily dose is 400 mcg (100 mcg in each nostril 2 times/day). Elderly patients are recommended average therapeutic dose intended for adults.
Children from 4 to 12 years are prescribed 50 mcg in each nostril 1 time per day, preferably in the morning; if necessary, the use can be increased up to 2 times per day. To guarantee maximum efficiency, it is important to use the drug regularly, in accordance with indications. The maximum effect occurs within 3-4 days of treatment.
For external use (cream, ointment):
Fluticasone in the form of a cream can be used in children older than 6 months, in the form of an ointment can be used in children older than 1 year. In the treatment of acute and chronic dermatoses in adults and children a thin layer of ointment or cream to affected skin 1-2 times/day.
To reduce the risk of recurrent disease after achieving a therapeutic effect in the acute phase of the frequency of application of a cream or ointment is reduced: it is recommended to apply the preparation once a week, two times without overlapping occlusive dressings. Applied to all previously affected skin or areas where you can expect the appearance of recurrent disease. Application fluticasone recommended combined with softening cosmetics.